Association of human rhinovirus infection with asthma in children / 中华实验和临床病毒学杂志

Asthma is a serious global health problem affecting all age groups. It has been recognized as a complex disease resulting from interactions between multiple genetic and environmental factors. Human rhinovirus (HRV) infections in early life constitute a major environmental risk factor for the development of childhood asthma and the most common cause of asthma exacerbation. HRV-C, the novel HRV, using cadherin-related family member 3 (CDHR3) as receptors, plays a key role in the development of childhood asthma. This review discusses the role and the potential underlying mechanisms of HRV infections in the development and exacerbation of childhood asthma based on recent clinical and experimental evidence.